Multiple Approaches for Ultrasonic Cavitation Monitoring of Oxygen-Loaded Nanodroplets

Ultrasound(US) is widely used in medical field for a variety diagnostic techniques but, in recent years, it has also been creating great interest for therapeutic aims. Regarding drug delivery, the use of US as an activation source provides better spatial delivery confinement and limits the undesired side effects. However, at present there is no complete characterization at a fundamental level of the different signals produced by sono-activated nanocarriers. Therefore, the aim of this study is to obtain a metrological characterization of the cavitation phenomena induced by US through three parallel investigation approaches. US was focused into a channel of a customized phantom in which a solution with oxygen-loaded nanodroplets (OLNDs) was led to flow and the cavitation activity was monitored. Both quantitative and qualitative real-time analysis were performed giving information about the dynamics of bubble formation, oscillation and final implosion with respect to the working acoustic pressure and the type of nanodroplets, compared with pure water. From this analysis a possible interpretation of the observed results is proposed

Delay tolerant networking in a shopping mall environment

The increasing popularity of computing devices with short-range wireless offers new communication service opportunities. These devices are small and may be mobile or embedded in almost any type of object imaginable, including cars, tools, appliances, clothing and various consumer goods. The majority of them can store data and transmit it when a wireless, or wired, transmitting medium is available. The mobility of the individuals carrying such short-range wireless devices is important because varying distances creates connection opportunities and disconnections. It is likely that successful forwarding algorithms will be based, at least in part, on the patterns of mobility that are seen in real settings. For this reason, studying human mobility in different environments for extended periods of time is essential. Thus we need to use measurements from realistic settings to drive the development and evaluation of appropriate forwarding algorithms. Recently, several significant efforts have been made to collect data reflecting human mobility. However, these traces are from specific scenarios and their validity is difficult to generalize. In this thesis we contribute to this effort by studying human mobility in shopping malls. We ran a field trial to collect real-world Bluetooth contact data from shop employees and clerks in a shopping mall over six days. This data will allow the informed design of forwarding policies and algorithms for such settings and scenarios, and determine the effects of users' mobility patterns on the prevalence of networking opportunities. Using this data set we have analysed human mobility and interaction patterns in this shopping mall environment. We present evidence of distinct classes of mobility in this situation and characterize them in terms of power law coefficients which approximate inter-contact time distributions. These results are quite different from previous studies in other environments. We have developed a software tool which implements a mobility model for "structured" scenarios such as shopping malls, trade fairs, music festivals, stadiums and museums. In this thesis we define as structured environment, a scenario having definite and highly organised structure, where people are organised by characteristic patterns of relationship and mobility. We analysed the contact traces collected on the field to guide the design of this mobility model. We show that our synthetic mobility model produces inter-contact time and contact duration distributions which approximate well to those of the real traces. Our scenario generator also implements several random mobility models. We compared our Shopping Mall mobility model to three other random mobility models by comparing the performances of two benchmark delay tolerant routing protocols, Epidemic and Prophet, when simulated with movement traces from each model. Thus, we demonstrate that the choice of a mobility model is a significant consideration when designing and evaluating delay-tolerant mobile ad-hoc network protocols. Finally, we have also conducted an initial study to evaluate the effect of delivering messages in shopping mall environments by exclusively forwarding them to customers or sellers, each of which has distinctive mobility patterns

Delay tolerant networking in a shopping mall environment

The increasing popularity of computing devices with short-range wireless offers new communication service opportunities. These devices are small and may be mobile or embedded in almost any type of object imaginable, including cars, tools, appliances, clothing and various consumer goods. The majority of them can store data and transmit it when a wireless, or wired, transmitting medium is available. The mobility of the individuals carrying such short-range wireless devices is important because varying distances creates connection opportunities and disconnections. It is likely that successful forwarding algorithms will be based, at least in part, on the patterns of mobility that are seen in real settings. For this reason, studying human mobility in different environments for extended periods of time is essential. Thus we need to use measurements from realistic settings to drive the development and evaluation of appropriate forwarding algorithms. Recently, several significant efforts have been made to collect data reflecting human mobility. However, these traces are from specific scenarios and their validity is difficult to generalize. In this thesis we contribute to this effort by studying human mobility in shopping malls. We ran a field trial to collect real-world Bluetooth contact data from shop employees and clerks in a shopping mall over six days. This data will allow the informed design of forwarding policies and algorithms for such settings and scenarios, and determine the effects of users' mobility patterns on the prevalence of networking opportunities. Using this data set we have analysed human mobility and interaction patterns in this shopping mall environment. We present evidence of distinct classes of mobility in this situation and characterize them in terms of power law coefficients which approximate inter-contact time distributions. These results are quite different from previous studies in other environments. We have developed a software tool which implements a mobility model for "structured" scenarios such as shopping malls, trade fairs, music festivals, stadiums and museums. In this thesis we define as structured environment, a scenario having definite and highly organised structure, where people are organised by characteristic patterns of relationship and mobility. We analysed the contact traces collected on the field to guide the design of this mobility model. We show that our synthetic mobility model produces inter-contact time and contact duration distributions which approximate well to those of the real traces. Our scenario generator also implements several random mobility models. We compared our Shopping Mall mobility model to three other random mobility models by comparing the performances of two benchmark delay tolerant routing protocols, Epidemic and Prophet, when simulated with movement traces from each model. Thus, we demonstrate that the choice of a mobility model is a significant consideration when designing and evaluating delay-tolerant mobile ad-hoc network protocols. Finally, we have also conducted an initial study to evaluate the effect of delivering messages in shopping mall environments by exclusively forwarding them to customers or sellers, each of which has distinctive mobility patterns

Lutzomyia longipalpis (Diptera, Psychodidae) in the Basaltic Cuesta at the hydrographic basin of the Corumbataí River, Central East Region of the State of São Paulo, Brazil

A incidência das leishmanioses tegumentar e visceral americanas, em especial esta última (LVA), em hospedeiros caninos e humanos, encontra-se em crescente processo de expansão no Estado de São Paulo. Para a vigilância epidemiológica dessas endemias, torna-se fundamental o conhecimento da distribuição e da ecologia das diferentes espécies da fauna flebotomínea vetoras. Assim, a divulgação de novos encontros de seus vetores, sobretudo da Lutzomyia longipalpis, o principal vetor da LVA, é fundamental para apontar novas áreas de risco para a transmissão dessas doenças. Neste estudo, capturas de flebotomíneos foram realizadas em ambiente domiciliar, peridomiciliar e de mata, em diferentes localidades rurais dos municípios de Ipeúna e Itirapina, entre outubro de 2001 e fevereiro de 2004. Foram utilizadas armadilhas luminosas automáticas do tipo CDC, das 18h às 8h, em 14 noites, resultando 420 horas de exposição. Foram capturados 177 flebotomíneos pertencentes a doze espécies. A espécie mais abundante, Nyssomyia neivai, apontada como a principal vetora de LTA no Estado, contribuiu com 85,4% dos espécimes capturados em Ipeúna. O encontro de Lutzomyia longipalpis em uma caverna em Itirapina, aponta para o risco de estabelecimento da LVA na área e a necessidade de mais estudos locais sobre sua ecologia, sobretudo em relação à ocupação de ambientes antrópicos.Cutaneous (LTA) and Visceral (LVA) American Leishmaniasis incidence is increasing in human and canine hosts, especially LVA, which is expanding throughout the State of São Paulo. Knowledge of the distribution and ecology of different sand fly species is essential for leishmaniasis epidemiological surveillance. The communication of new findings of vectors, mainly the main LVA vector Lutzomyia longipalpis, is mandatory for determination of these illnesses' transmission risk. In this study, sand flies were trapped in domiciliary, peridomiciliary and bushed areas, in different localities in rural areas of the Ipeúna and Itirapina counties, between October 2001 and February 2004. CDC automatic light traps were used from 18h to 8h, during 14 nights, resulting in 420 hours of captures. A total of 177 specimens pertaining to twelve different species were sampled. The most abundant species was Nyssomyia neivai, pointed out as the main LTA vector in the State of São Paulo, which totaled 85.4% of the specimens trapped in Ipeúna. The finding of Lutzomyia longipalpis in a cave in Itirapina indicates the risk of LVA establishment in the area and the need for new local studies on its ecology, especially with regard to occupation of anthropic environments

Lutzomyia longipalpis (Diptera, Psychodidae) in the Basaltic Cuesta at the hydrographic basin of the Corumbataí River, Central East Region of the State of São Paulo, Brazil

A incidência das leishmanioses tegumentar e visceral americanas, em especial esta última (LVA), em hospedeiros caninos e humanos, encontra-se em crescente processo de expansão no Estado de São Paulo. Para a vigilância epidemiológica dessas endemias, torna-se fundamental o conhecimento da distribuição e da ecologia das diferentes espécies da fauna flebotomínea vetoras. Assim, a divulgação de novos encontros de seus vetores, sobretudo da Lutzomyia longipalpis, o principal vetor da LVA, é fundamental para apontar novas áreas de risco para a transmissão dessas doenças. Neste estudo, capturas de flebotomíneos foram realizadas em ambiente domiciliar, peridomiciliar e de mata, em diferentes localidades rurais dos municípios de Ipeúna e Itirapina, entre outubro de 2001 e fevereiro de 2004. Foram utilizadas armadilhas luminosas automáticas do tipo CDC, das 18h às 8h, em 14 noites, resultando 420 horas de exposição. Foram capturados 177 flebotomíneos pertencentes a doze espécies. A espécie mais abundante, Nyssomyia neivai, apontada como a principal vetora de LTA no Estado, contribuiu com 85,4% dos espécimes capturados em Ipeúna. O encontro de Lutzomyia longipalpis em uma caverna em Itirapina, aponta para o risco de estabelecimento da LVA na área e a necessidade de mais estudos locais sobre sua ecologia, sobretudo em relação à ocupação de ambientes antrópicos.Cutaneous (LTA) and Visceral (LVA) American Leishmaniasis incidence is increasing in human and canine hosts, especially LVA, which is expanding throughout the State of São Paulo. Knowledge of the distribution and ecology of different sand fly species is essential for leishmaniasis epidemiological surveillance. The communication of new findings of vectors, mainly the main LVA vector Lutzomyia longipalpis, is mandatory for determination of these illnesses' transmission risk. In this study, sand flies were trapped in domiciliary, peridomiciliary and bushed areas, in different localities in rural areas of the Ipeúna and Itirapina counties, between October 2001 and February 2004. CDC automatic light traps were used from 18h to 8h, during 14 nights, resulting in 420 hours of captures. A total of 177 specimens pertaining to twelve different species were sampled. The most abundant species was Nyssomyia neivai, pointed out as the main LTA vector in the State of São Paulo, which totaled 85.4% of the specimens trapped in Ipeúna. The finding of Lutzomyia longipalpis in a cave in Itirapina indicates the risk of LVA establishment in the area and the need for new local studies on its ecology, especially with regard to occupation of anthropic environments.11233633

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe